BioArtist
Projects
The Scientist
The BioArtist
Viral Symmetries
Cellular Entities
Cellular Portrait
BioArtist
Dulbecco (b. 1985) is a Costa Rican emerging BioArtist, whose works are abstractions and allegories of the macroscopic world into the microscopic/molecular universe and vice versa, focusing on what he describes as “inherent philosophical issues of postmodernity ”. He implements photomicrography of microorganisms and mammalian cells to express his art, also combining it with digital tools to create full audiovisual works. Dulbecco blends science and art by repurposing cutting-edge cell biology laboratory techniques to tackle artistic questionings. For example, he applies genetic engineering and recombinant DNA technology to codify different colors into animal cells and make them glow for artistic purposes by the expression of fluorescent proteins, a concept he has named “recombinant hues”.
Dulbecco proposes a new trend in BioArt, which not only uses biological elements in the technique, but also involves social and cultural aspects of the viewer in the artistic process. His background is biological sciences with more than sixteen years of experience as researcher for the Research Center on Tropical Diseases of the University of Costa Rica. Dulbecco has published several original articles in scientific journals, describing new molecular tools that he has developed for research in Virology and that he has also applied in the creation of his own artistic works. Currently he is cathedratic professor in Cell & Molecular Biology at the Microbiology Faculty of the University of Costa Rica.
Education
- 2008 Licentiate degree in Microbiology and Clinical Chemistry (Lic.), University of Costa Rica
- 2013 Master’s degree in Microbiology (M.Sc.), University of Costa Rica
- 2021 Doctoral degree in Science (Ph.D.), University of Costa Rica
Journal articles
- 2018 Arias-Arias J.L., Vega-Aguilar F., Corrales-Aguilar E., Hun L., Loría G.D., and Mora-Rodríguez R. Dengue virus infection of primary human smooth muscle cells. Am J Trop Med Hyg. 99: 1451-1457. doi: 10.4269/ajtmh.18-0175
- 2018 Alvarado A., Corrales R., Leal M., De la Ossa A., Arroyo M., Gomez A., Calderón A., Arias-Arias J.L., and Mora R. Cellular-level characterization of dengue and zika virus infection using multiagent simulation. IEEE International Work Conference on Bioinspired Intelligence (IWOBI) pp. 1-6. doi: 10.1109/IWOBI.2018.8464219
- 2020 Arias-Arias J.L., MacPherson D.J., Hill M.E., Hardy J.A., and Mora-Rodríguez R. A fluorescence-activatable reporter of flavivirus NS2B-NS3 protease activity enables live imaging of infection in single cells and viral plaques. J Biol Chem. 295: 2212-2226. doi: 10.1074/jbc.RA119.011319
- 2021 Arias-Arias J.L., and Mora-Rodríguez R. Generation and implementation of reporter BHK-21 cells for live imaging of flavivirus infection. Bio-protocol 11(5): e3942. doi: 10.21769/BioProtoc.3942
- 2021 Arias-Arias J.L., Corrales-Aguilar E., and Mora-Rodríguez R. A fluorescent real-time plaque assay enables single-cell analysis of virus-induced cytopathic effect by Live cell imaging. Viruses 13: 1193. doi: 10.3390/v13071193
- 2021 Arias-Arias J.L., Vega-Aguilar F., Picado-Soto D., Corrales-Aguilar E., and Loría G.D. In vitro inhibition of Zika virus replication with amantadine and rimantadine hydrochlorides. Microbiol. Res. 12: 727-738. doi: 10.3390/microbiolres12030052
- 2021 Quiros-Fernandez I., Figueroa-Protti L., Arias-Arias J.L., Brenes-Cordero N., Siles F., Mora J, Mora-Rodríguez R.A. Perturbation-based modeling unveils the autophagic modulation of chemosensitivity and immunogenicity in breast cancer cells. Metabolites 11: 637. doi: 10.3390/metabo11090637
- 2021 Acón M., Geiß C., Torres-Calvo J., Bravo-Estupiñan D., Oviedo G., Arias-Arias J.L., Rojas-Matey L.A., Baez E., Vásquez-Vargas G., Oses-Vargas Y., Guevara-Coto J., Segura-Castillo A., Siles-Canales F., Quirós-Barrantes S., Régnier-Vigouroux A., Mendes P., Mora-Rodríguez R. MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer. iScience 24: 103407. doi: 10.1016/j.isci.2021.103407
- 2023 Arias-Arias J.L., Molina-Castro S.E., Monturiol-Gross L., Lomonte B., and Corrales-Aguilar E., Stable production of recombinant SARS-CoV-2 receptor-binding domain in mammalian cells with co-expression of a fluorescent reporter and its validation as antigenic target for COVID-19 serology testing. Biotechnology Reports 37, e00780. doi: 10.1016/j.btre.2022.e00780.
Book chapters
- 2021 Arias-Arias J.L., and Mora-Rodríguez R. Fluorescence imaging approaches in flavivirus research. In Human Viruses: Diseases, treatments and vaccines, pp 713–729, Springer Link. doi: 10.1007/978-3-030-71165-8_34
- 2023 Arias-Arias J.L., and Céspedes-Tenorio D. The virus-induced cytopathic effect. In Virus Infected Cells, Springer Link. doi: 10.1007/978-3-031-40086-5
Group exhibitions
- 2011 Expo Foto, La Casa del Cuño, Antigua Aduana, San José, Costa Rica
- 2017 La No Bienal, Gráfica Genesis, San José, Costa Rica
- 2024 Amalgama: Uniendo la Ciencia y el Arte, Universidad de Costa Rica, San José, Costa Rica